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Sheep with partial RXFP2 knockout exhibit normal horn phenotype but unilateral cryptorchidism

Yawei Gao1, Siyuan Xi1, Bei Cai2, Tingjie Wu1, Qian Wang3, Peter Kalds1, Shuhong Huang1, Yuhui Wang1, Saizheng Han1, Menghao Pan4, Chong Yang3, Qifang Kou5, Baohua Ma4, Xiaolong Wang1,6( ), Shiwei Zhou1,4( ), Yulin Chen1,6( )
Key Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, Yangling 712100, China
Key Laboratory of Ruminant Molecular and Cellular Breeding of Ningxia Hui Autonomous Region, College of Animal Science and Technology, Ningxia University, Yinchuan 750021, China
Animal Husbandry Workstation of Ningxia Hui Autonomous Region, Jinfeng 750002, China
College of Veterinary Medicine, Northwest A&F University, Yangling 712100, China
Ningxia Tianyuan Tan Sheep Farm, Wuzhong 751900, China
Key Laboratory of Livestock Biology, Northwest A&F University, Yangling 712100, China
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Highlights

  • CRISPR/Cas9 RNP complex-based strategy demonstrates robustness and accuracy in generating gene-edited sheep.

  • Sheep horn development remains unaffected by partial RXFP2 knockout.

  • Partial RXFP2 knockout results in unilateral cryptorchidism in sheep.

References

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Journal of Integrative Agriculture (JIA)
Volume 24 Issue 9,
September 2025
Pages 3698-3702
DOI: 10.1016/j.jia.2023.11.045

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Cite this article:
Gao Y, Xi S, Cai B, et al. Sheep with partial RXFP2 knockout exhibit normal horn phenotype but unilateral cryptorchidism. Journal of Integrative Agriculture (JIA), 2025, 24(9): 3698-3702. https://doi.org/10.1016/j.jia.2023.11.045

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Received: 25 July 2023
Revised: 28 August 2023
Accepted: 30 October 2023
Published: 28 November 2023
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