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Case Report | Open Access

Culture-negative liver abscess identified with plasma microbial cell-free DNA sequencing: A case report

Yuanchao Xue, Filipe M. Cerqueira, Heather L. Stevenson, Natalie Williams-Bouyer, Rong Fang( )
Department of Pathology, University of Texas Medical Branch at Galveston, Galveston, TX 77555, USA
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Highlights

• We report, for the first time, the identification of Streptococcus intermedius in plasma by metagenomic sequencing, the Karius Test, as the etiological organism of pyogenic liver abscesses.

• Deep sequencing of plasma may represent a less invasive laboratory diagnostic method for the etiological identification of liver abscesses.

• It warrants further investigation whether elevated blood iron levels predispose individuals to an increased risk of developing multiple pyogenic liver abscesses.

Abstract

Pyogenic liver abscess (PLA) is a potentially life-threatening disease. Early diagnosis and appropriate treatment are crucial to ensure high-quality healthcare for patients with PLA. However, this is complicated by their non-specific clinical symptoms. In addition, the etiologic organisms responsible for PLA are frequently culture-negative, thus complicating clinical decision-making. Here, we report a case of PLA caused by Streptococcus intermedius, as identified via DNA metagenomic sequencing of plasma.

Keywords

Pyogenic liver abscessStreptococcus anginosus groupNext-generation sequencing

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Infectious Medicine
Volume 4 Issue 2,
June 2025
Article number: 100180
DOI: 10.1016/j.imj.2025.100180

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Cite this article:
Xue Y, Cerqueira FM, Stevenson HL, et al. Culture-negative liver abscess identified with plasma microbial cell-free DNA sequencing: A case report. Infectious Medicine, 2025, 4(2): 100180. https://doi.org/10.1016/j.imj.2025.100180

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Received: 22 December 2024
Revised: 09 February 2025
Accepted: 27 February 2025
Published: 01 June 2025
© 2025 The Author(s).

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)