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Infectious Medicine 2023, 2(2): 67-73 https://doi.org/10.1016/j.imj.2023.04.003
Review | Open Access | Issue | Published: 23 April 2023

Association between Hepatitis B virus and gastric cancer: A systematic review and meta-analysis

Show Author's Information Rong Yua,  Jingru Huangb,  Hewei Penga,  Shuo Yina,  Weijiang Xiea,  Shutong Rena,  Xian-E Penga,c( )
Department of Epidemiology and Health Statistics, Fujian Provincial Key Laboratory of Environment Factors and Cancer, School of Public Health, Fujian Medical University, Fuzhou 350122, China
Department of Clinical Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou 350108, China
Key Laboratory of Ministry of Education for Gastrointestinal Cancer, Fujian Medical University, Fuzhou 350108, China
Keywords:
Meta-analysis, Gastric cancer, Hepatitis B virus
Cite this article:
Yu R, Huang J, Peng H, et al. Association between Hepatitis B virus and gastric cancer: A systematic review and meta-analysis. Infectious Medicine, 2023, 2(2): 67-73. https://doi.org/10.1016/j.imj.2023.04.003
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Abstract Full text Electronic supplementary material About this article

An increasing number of studies are suggesting that hepatitis B virus (HBV) infection may be associated with an increased risk of not only hepatocellular carcinoma but also gastric cancer (GC). Whether HBV infection can be a risk factor for GC remains to be explored. In this study, we systematically searched for all eligible literature in 7 databases (China National Knowledge Infrastructure, WanFang, China Science and Technology Journal, PubMed, Cochrane Library, Web of Science and Embase). Eligible studies were required to have a case-control or cohort design. Sixteen studies were included and a meta-analysis was performed using Stata version 17.0. The quality of the included studies was assessed using the Newcastle-Ottawa Scale. The association between HBV infection and risk of GC was quantified by calculating the odds ratio and 95% confidence interval. The proportion of high-quality studies was 87.5% (14/16). The risk of GC was higher when HBV infection was present than when it was not (combined odds ratio 1.29, 95% confidence interval 1.16–1.44; I2 = 62.7%, p < 0.001). The results of subgroup analyses were consistent with the main results. In conclusion, this systematic review and meta-analysis identified a positive association between HBV infection and an increased risk of GC.


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Electronic supplementary material
About this article

Association between Hepatitis B virus and gastric cancer: A systematic review and meta-analysis

Show Author's information Rong Yua, Jingru Huangb, Hewei Penga, Shuo Yina, Weijiang Xiea, Shutong Rena, Xian-E Penga,c( )
Department of Epidemiology and Health Statistics, Fujian Provincial Key Laboratory of Environment Factors and Cancer, School of Public Health, Fujian Medical University, Fuzhou 350122, China
Department of Clinical Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou 350108, China
Key Laboratory of Ministry of Education for Gastrointestinal Cancer, Fujian Medical University, Fuzhou 350108, China

Abstract

An increasing number of studies are suggesting that hepatitis B virus (HBV) infection may be associated with an increased risk of not only hepatocellular carcinoma but also gastric cancer (GC). Whether HBV infection can be a risk factor for GC remains to be explored. In this study, we systematically searched for all eligible literature in 7 databases (China National Knowledge Infrastructure, WanFang, China Science and Technology Journal, PubMed, Cochrane Library, Web of Science and Embase). Eligible studies were required to have a case-control or cohort design. Sixteen studies were included and a meta-analysis was performed using Stata version 17.0. The quality of the included studies was assessed using the Newcastle-Ottawa Scale. The association between HBV infection and risk of GC was quantified by calculating the odds ratio and 95% confidence interval. The proportion of high-quality studies was 87.5% (14/16). The risk of GC was higher when HBV infection was present than when it was not (combined odds ratio 1.29, 95% confidence interval 1.16–1.44; I2 = 62.7%, p < 0.001). The results of subgroup analyses were consistent with the main results. In conclusion, this systematic review and meta-analysis identified a positive association between HBV infection and an increased risk of GC.

Keywords: Meta-analysis, Gastric cancer, Hepatitis B virus

References(34)

[1]

LSY Tang, E Covert, E Wilson, et al., Chronic hepatitis B infection: a review, JAMA 319 (17) (2018) 1802–1813, doi:10.1001/jama.2018.3795.
DOI Google Scholar
[2]

YF Liaw, CM. Chu, Hepatitis B virus infection, Lancet 373 (9663) (2009) 582–592, doi:10.1016/s0140-6736(09)60207-5.
DOI Google Scholar
[3]

T Tian, C Song, L Jiang, J Dai, et al., Hepatitis B virus infection and the risk of cancer among the Chinese population, Int. J. Cancer 147 (11) (2020) 3075–3084, doi:10.1002/ijc.33130.
DOI Google Scholar
[4]

CY Hong, DH Sinn, D Kang, et al., Incidence of extrahepatic cancers among individuals with chronic hepatitis B or C virus infection: a nationwide cohort study, J. Viral Hepat. 27 (9) (2020) 896–903, doi:10.1111/jvh.13304.
DOI Google Scholar
[5]

H Sung, J Ferlay, RL Siegel, et al., Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries, CA Cancer J. Clin. 71 (3) (2021) 209–249, doi:10.3322/caac.21660.
DOI Google Scholar
[6]

H Cui, Y Jin, F Chen, et al., Clinicopathological evidence of hepatitis B virus infection in the development of gastric adenocarcinoma, J. Med. Virol. 92 (1) (2020) 71–77, doi:10.1002/jmv.25584.
DOI Google Scholar
[7]

YS Yang, ZF Jiang, WZ Wu, et al., Chronic hepatitis virus infection are associated with high risk of gastric cancer: a systematic review and cumulative analysis, Front. Oncol. 11 (7) (2021) 703558, doi:10.3389/fonc.2021.703558.
DOI Google Scholar
[8]

C Song, J Lv, Y Liu, et al., Associations between hepatitis b virus infection and risk of all cancer types, JAMA Netw. Open 2 (6) (2019) e195718, doi:10.1001/jamanetworkopen.2019.5718.
DOI Google Scholar
[9]

M Li, S Wu, H Luo, et al., Serological and molecular characterization of hepatitis B virus infection in gastric cancer, Front. Cell. Infect. Microbiol. 12 (5) (2022) 894836, doi:10.3389/fcimb.2022.894836.
DOI Google Scholar
[10]

PR Spradling, J Xing, YN Zhong, et al., Incidence of malignancies among patients with chronic hepatitis B in US Health Care Organizations, 2006-2018, J. Infect. Dis. 226 (5) (2022) 896–900, doi:10.1093/infdis/jiac011.
DOI Google Scholar
[11]

A. Stang, Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses, Eur. J. Epidemiol. 25 (9) (2010) 603–605, doi:10.1007/s10654-010-9491-z.
DOI Google Scholar
[12]

HX Cui, YZ Jin, F Chen, et al., Clinicopathological evidence of hepatitis B virus infection in the development of gastric adenocarcinoma, J. Med. Virol. 92 (1) (2020) 71–77, doi:10.1002/jmv.25584.
DOI Google Scholar
[13]

Y Gong, YS Yang, XM Zhang, et al., ABO blood type, diabetes and risk of gastrointestinal cancer in northern China, World J. Gastroenterol. 18 (6) (2012) 563–569, doi:10.3748/wjg.v18.i6.563.
DOI Google Scholar
[14]

P Mahale, EA Engels, J. Koshiol, Hepatitis B virus infection and the risk of cancer in the elderly US population, Int. J. Cancer 144 (3) (2019) 431–439, doi:10.1002/ijc.31643.
DOI Google Scholar
[15]

T Tian, C Song, LF Jiang, et al., Hepatitis B virus infection and the risk of cancer among the Chinese population, Int. J. Cancer 147 (11) (2020) 3075–3084, doi:10.1002/ijc.33130.
DOI Google Scholar
[16]

H Wang, XZ Chen, XL Chen, et al., Associations between hepatitis B virus exposure and the risk of extrahepatic digestive system cancers: a hospital-based, case-control study (SIGES), Cancer Med. 10 (11) (2021) 3741–3755, doi:10.1002/cam4.3901.
DOI Google Scholar
[17]

XL Wei, HY Luo, CF Li, et al., Hepatitis B virus infection is associated with younger median age at diagnosis and death in cancers, Int. J. Cancer 141 (1) (2017) 152–159, doi:10.1002/ijc.30719.
DOI Google Scholar
[18]

XL Wei, MZ Qiu, Y Jin, et al., Hepatitis B virus infection is associated with gastric cancer in China: an endemic area of both diseases, Br. J. Cancer 112 (7) (2015) 1283–1290, doi:10.1038/bjc.2014.406.
DOI Google Scholar
[19]

Q Wu, XD He, L Yu, et al., The metabolic syndrome and risk factors for biliary tract cancer: a case-control study in China, Asian Pac. J. Cancer Prev. 13 (5) (2012) 1963–1969, doi:10.7314/apjcp.2012.13.5.1963.
DOI Google Scholar
[20]

C Song, J Lv, Y Liu, et al., Associations between hepatitis B virus infection and risk of all cancer types, JAMA Netw. Open 2 (6) (2019), doi:10.1001/jamanetworkopen.2019.5718.
DOI Google Scholar
[21]

AB Kamiza, FH Su, WC Wang, et al., Chronic hepatitis infection is associated with extrahepatic cancer development: a nationwide population-based study in Taiwan, BMC Cancer 16 (1) (2016) 861, doi:10.1186/s12885-016-2918-5.
DOI Google Scholar
[22]

T Liu, CH Song, YC Zhang, et al., Hepatitis B virus infection and the risk of gastrointestinal cancers among Chinese population: a prospective cohort study, Int. J. Cancer 150 (6) (2022) 1018–1028, doi:10.1002/ijc.33891.
DOI Google Scholar
[23]

N Motamed-Gorji, S Eghtesad, M Sharafkhah, et al., All-cause and cause-specific mortality in middle-aged individuals with positive HBsAg: findings from a prospective cohort study, Arch. Iran. Med. 25 (3) (2022) 139–147, doi:10.34172/aim.2022.24.
DOI Google Scholar
[24]

F Peng, D.E. Chen, The Relationship between Gastric Cacinoma and Hepatitis B Virus Infection., J. of Pub. Health and Prev. Med. 16 (3) (2005) 12–14 In chinese.
Google Scholar
[25]

J An, J.W. Kim, J.H Shim, et al., Chronic hepatitis B infection and non-hepatocellular cancers: A hospital registry-based, case-control study., PLoS One 13 (3) (2018) e0193232, doi:10.1371/journal.pone.0193232.
DOI Google Scholar
[26]

AB Kamiza, S Fatumo, MG Singini, et al., Hepatitis B infection is causally associated with extrahepatic cancers: a Mendelian randomization study, EBioMedicine 79 (5) (2022) 104003, doi:10.1016/j.ebiom.2022.104003.
DOI Google Scholar
[27]

H Wang, XL Chen, K Liu, et al., Associations between gastric cancer risk and virus infection other than epstein-barr virus: a systematic review and metaanalysis based on epidemiological studies, Clin. Transl. Gastroenterol. (7) (2020), doi:10.14309/ctg.0000000000000201.
DOI Google Scholar
[28]

W Wongtrakul, N Charoenngam, B Ponvilawan, et al., Hepatitis B virus infection and risk of gastric cancer: a systematic review and meta-analysis, Minerva Gastroenterol. (Torino) (7) (2021), doi:10.23736/s2724-5985.21.02946-6.
DOI Google Scholar
[29]

M Baghbanian, SA Hoseini Mousa, M Doosti, et al., Association between gastric pathology and hepatitis B virus infection in patients with or without Helicobacter Pylori, Asian Pac. J. Cancer Prev. 20 (7) (2019) 2177–2180, doi:10.31557/apjcp.2019.20.7.2177.
DOI Google Scholar
[30]

S Gu, W Wang, G Ye, et al., Hepatocyte-derived L-carnitine restricts hepatitis B surface antigen loss through an immunosuppressive effect on germinal center-related immune cells, J. Infect. Dis. 225 (11) (2022) 1955–1966, doi:10.1093/infdis/jiab344.
DOI Google Scholar
[31]

S Fattahi, N Nikbakhsh, H Taheri, et al., Prevalence of multiple infections and the risk of gastric adenocarcinoma development at earlier age, Diagn. Microbiol. Infect. Dis. 92 (1) (2018) 62–68, doi:10.1016/j.diagmicrobio.2018.04.015.
DOI Google Scholar
[32]

KS Jeng, CF Chang, IS Sheen, et al., Upper gastrointestinal cancer and liver cirrhosis, Cancers (Basel) 14 (9) (2022), doi:10.3390/cancers14092269.
DOI Google Scholar
[33]

J Xiao, F Wang, NK Wong, et al., Global liver disease burdens and research trends: analysis from a Chinese perspective, J. Hepatol. 71 (1) (2019) 212–221, doi:10.1016/j.jhep.2019.03.004.
DOI Google Scholar
[34]

KV Kowdley, CC Wang, S Welch, et al., Prevalence of chronic hepatitis B among foreign-born persons living in the United States by country of origin, Hepatology 56 (2) (2012) 422–433, doi:10.1002/hep.24804.
DOI Google Scholar
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Received: 02 March 2023
Revised: 23 March 2023
Accepted: 01 April 2023
Published: 23 April 2023
Issue date: June 2023

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© 2023 The Authors. Tsinghua University Press.

Acknowledgements

The authors would like to express their gratitude to all the study participants for their cooperation.

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This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)

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