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Letter | Open Access

Conserved nucleocapsid epitopes induce cross-reactive CD4+ T-cell responses with selective protection against human coronaviruses in mice

Xiaomin Lai1,2,3,#, Zhao Chen1,#, Suoqun Zhao1,4,#, Airu Zhu1,#, Jian Zheng5,#, Zhaoyong Zhang1,#, Junxiang Wang1, Yanqun Wang1, Jing Sun1, Fang Li1, Yihao Li1, Jiamin Liu1, Stanley Perlman5( ), Jingxian Zhao1,4,6( ), Jincun Zhao1,4,6,7( ), Zhen Zhuang1( )
State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Joint International Research Laboratory of Respiratory Health, Guangdong Basic Research Center of Excellence for Respiratory Medicine, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangdong, China
Shenzhen Third Children’s Hospital, Guangdong, China
Shenzhen Maternity and Child Healthcare Hospital, Guangdong, China
Guangzhou National Laboratory, Guangdong, China
Department of Microbiology and Immunology, University of Iowa, Iowa, USA
School of Basic Medical Sciences, Guangzhou Medical University, Guangdong, China
Shanghai Institute for Advanced Immunochemical Studies, School of Life Science and Technology, ShanghaiTech University, Shanghai, China

#These authors contributed equally to this work

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hLife
Volume 4 Issue 9,
September 2026
Pages 596-600
DOI: 10.1016/j.hlife.2026.07.004

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Cite this article:
Lai X, Chen Z, Zhao S, et al. Conserved nucleocapsid epitopes induce cross-reactive CD4+ T-cell responses with selective protection against human coronaviruses in mice. hLife, 2026, 4(9): 596-600. https://doi.org/10.1016/j.hlife.2026.07.004

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Received: 16 April 2026
Revised: 16 July 2026
Accepted: 22 July 2026
Published: 01 September 2026
© 2026 The Author(s).

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).