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Letter | Open Access

Polyfunctional varicella-zoster virus–reactive memory CD4+ T cells reside in human bone marrow

Zixu Wang1,2, Simon Reinke3, Yu Shen1,2, Xiangyi Deng1,2, Tobias Alexander4, Anne Claußnitzer4, Sebastian Hardt5, Luis Becker5, Koji Tokoyoda6, Carsten Perka5, Andreas Radbruch1( ), Jun Dong1( )
Department of Cell Biology, Deutsches Rheuma-Forschungszentrum Berlin, an Institute of the Leibniz Association, Berlin, Germany
Charité Graduate School, Charité–Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany
BIH-Center for Regenerative Therapies (BCRT), Berlin Institute of Health (BIH) at Charité-Universitätsmedizin Berlin, Berlin, Germany
Medizinische Klinik mit Schwerpunkt Rheumatologie und Klinische Immunologie, Charité–Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany
Department of Orthopedics, Center for Musculoskeletal Surgery, Charité–Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany
Division of Immunology, Tottori University, Tottori Prefecture, Japan
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hLife
Volume 4 Issue 7,
July 2026
Pages 457-460
DOI: 10.1016/j.hlife.2026.04.001

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Cite this article:
Wang Z, Reinke S, Shen Y, et al. Polyfunctional varicella-zoster virus–reactive memory CD4+ T cells reside in human bone marrow. hLife, 2026, 4(7): 457-460. https://doi.org/10.1016/j.hlife.2026.04.001

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Received: 05 February 2026
Revised: 16 March 2026
Accepted: 03 April 2026
Published: 01 July 2026
© 2026 The Author(s).

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).