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Perspective | Open Access

Decoding vaccine-induced immunity: From systems vaccinology to artificial intelligence–driven precision vaccines

Rong Wang1,2,3,4, Huajie Hu1,2, Yanli Chen1,2, Wei Yang1,2, Chunmei Li1,2, Mengjie Chen5( ), Rui Cheng1,2( ), Zijie Zhang1,2,6( )
Bio-X Center for Interdisciplinary Innovation, Yunnan University, Yunnan, China
Yunnan Vaccine Laboratory, Yunnan, China
State Key Laboratory of Genetic Evolution & Animal Models and Yunnan Key Laboratory of Molecular Biology of Domestic Animals, Kunming Institute of Zoology, Chinese Academy of Sciences, Yunnan, China
Kunming College of Life Science, University of Chinese Academy of Sciences, Yunnan, China
Department of Medicine, Department of Human Genetics, and Department of Statistics, University of Chicago, Chicago, USA
Southwest United Graduate School, Yunnan, China
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hLife
Volume 4 Issue 4,
April 2026
Pages 229-232
DOI: 10.1016/j.hlife.2025.11.001

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Cite this article:
Wang R, Hu H, Chen Y, et al. Decoding vaccine-induced immunity: From systems vaccinology to artificial intelligence–driven precision vaccines. hLife, 2026, 4(4): 229-232. https://doi.org/10.1016/j.hlife.2025.11.001

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Received: 26 August 2025
Revised: 08 November 2025
Accepted: 10 November 2025
Published: 01 April 2026
© 2025 The Author(s).

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).