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Perspective | Open Access

Mighty oaks from little acorns: High-quality genomes of underrepresented populations enhance health equity in precision medicine

Mengge Wang1,2,3,#, Lintao Luo1,2,3,#, Hui-Yuan Yeh4, Chuan-Chao Wang5, Huijun Yuan1,2, Chao Liu6( ), Renkuan Tang3( ), Guanglin He1,2,#( )
Center for Archaeological Science, Sichuan University, Sichuan, China
Department of Oto-Rhino-Laryngology, Institute of Rare Diseases, West China Hospital of Sichuan University, Sichuan University, Sichuan, China
Department of Forensic Medicine, College of Basic Medicine, Chongqing Medical University, Chongqing, China
School of Humanities, Nanyang Technological University, Singapore
Ministry of Education Key Laboratory of Contemporary Anthropology, Department of Anthropology and Human Genetics, School of Life Sciences, Fudan University, Shanghai, China
Anti-Drug Technology Center of Guangdong Province, Guangdong, China

#These authors contributed equally to this work

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hLife
Volume 3 Issue 12,
December 2025
Pages 621-625
DOI: 10.1016/j.hlife.2025.05.014

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Cite this article:
Wang M, Luo L, Yeh H-Y, et al. Mighty oaks from little acorns: High-quality genomes of underrepresented populations enhance health equity in precision medicine. hLife, 2025, 3(12): 621-625. https://doi.org/10.1016/j.hlife.2025.05.014

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Received: 19 March 2025
Revised: 13 May 2025
Accepted: 30 May 2025
Published: 01 December 2025
© 2025 The Author(s).

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).