Beyond recanalisation: The ATTRACTION trial shows a promising role for tirofiban after successful thrombectomy

Despite successful thrombectomy, many patients with large-vessel occlusion stroke remain functionally dependent. The ATTRACTION trial evaluated low-dose tirofiban after successful endovascular reperfusion and showed a modest improvement in 90-day functional independence without a statistically significant increase in symptomatic intracranial haemorrhage. The benefit appeared greater in patients with large-artery atherosclerosis and possibly those with incomplete reperfusion, whereas patients with cardioembolic stroke showed less favourable profiles. Compared with previous negative adjunctive antithrombotic trials, ATTRACTION highlights the importance of timing, dose, and delivery route. Further studies are needed to refine patient selection and balance functional benefit against haemorrhagic risk.