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Review Article | Open Access

Effectiveness of 3D printed and mixed reality models in neurosurgical patient education: A systematic review

Stefanie Bauera,b( ), Joshua Haeglera, Debora Cipriania, Markus Brudera,c, Julien Josta, Miriam Weissa,d, Christian Musahla, Pasquale Mordasinib,e, Gerrit A. Schuberta,f, Serge Marbachera,b, Lukas Andereggena,b
Department of Neurosurgery, Kantonsspital Aarau, Aarau, Switzerland
Faculty of Medicine, University of Bern, Bern, Switzerland
Department of Neurosurgery, University Hospital, Goethe University, Frankfurt am Main, Germany
Department of Neurosurgery, Inselspital, University Hospital Bern, Bern, Switzerland
Department of Neuroradiology, Kantonsspital Aarau, Aarau, Switzerland
Department of Neurosurgery, RWTH Aachen University Hospital Aachen, Aachen, Germany

Peer review under the responsibility of Editorial Board of Brain Hemorrhages.

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Abstract

Objective

Neurosurgical patients often face psychological distress due to difficulty understanding their medical condition and treatment plan. Traditional educational tools like MRI or CT scans may not effectively convey this information. 3D-printed models and mixed reality (MR) devices have emerged as innovative tools to improve patient communication with physicians. This systematic review evaluates their effectiveness in neurosurgical patient education.

Methods

Following PRISMA guidelines, a systematic literature search of PubMed/MEDLINE was conducted from inception to March 2024. Study eligibility was assessed using the PICOS framework in qualitative synthesis. Data on 3D printed and MR models for patient education in neurosurgery were extracted. Evidence quality was evaluated using OCEBM (Oxford Centre of Evidence Based Medicine) levels of evidence.

Results

The search found 61 articles, with 17 meeting eligibility criteria. Most offered low-level evidence but consistently demonstrated that 3D-printed and MR models enhance patient understanding of diagnoses and treatment plans by improving visualization of neurosurgical pathologies and key anatomical structures.

Conclusion

Our systematic review highlights the potential of 3D-printed and MR models in patient education by improving visualization of pathologies and critical anatomical structures. However, further research is needed to standardize methodologies, validate their effectiveness and integrate these tools into clinical practice.

References

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Brain Hemorrhages
Pages 285-292

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Cite this article:
Bauer S, Haegler J, Cipriani D, et al. Effectiveness of 3D printed and mixed reality models in neurosurgical patient education: A systematic review. Brain Hemorrhages, 2026, 7(5): 285-292. https://doi.org/10.1016/j.hest.2025.08.002

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Received: 18 February 2025
Revised: 18 August 2025
Accepted: 19 August 2025
Published: 05 September 2025
© 2025 International Hemorrhagic Stroke Association.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).