Relationships between NT-pro-BNP and other serological indicators and the prognosis of spontaneous intracerebral hemorrhage

Acute spontaneous intracerebral hemorrhage (ICH) is a life-threatening condition, and certain serological indicators may be associated with the prognosis after ICH. This study investigated the relationship between N-terminal pro-B-type natriuretic peptide (NT-pro-BNP) and other serological indicators with prognosis 90 days after the onset of acute ICH.

The general information, clinical, and follow-up data of patients with ICH who were admitted to the Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology from January 2019 to September 2022 were retrospectively collected. Based on the modified Rankin Scale (mRS) at 90 days of onset, the patients were divided into poor prognosis group (mRS > 3) and good prognosis group (mRS ≤ 3), and the differences in various indicators between these two groups were compared. Serological indicators related to prognosis were determined by univariate and multivariate logistic regression analysis, and the predictive value was evaluated by receiver operating characteristic (ROC) analysis and decision curve analysis (DCA).

A total of 121 patients with ICH were included in the study with 49 patients having a good prognosis and 72 patients having a poor prognosis. Multivariate logistic regression analysis showed that NT-pro-BNP at admission was associated with prognosis at 90 days after ICH onset (P < 0.05). ROC and DCA analyses demonstrated that NT-pro-BNP had a certain predictive ability for ICH prognosis.

The level of NT-pro-BNP at admission may be an independent risk factor for predicting prognosis at 90 days after the onset of ICH. The higher the level, the worse the prognosis may be.