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Rapid Communication | Open Access

Single-cell transcriptomics reveals EpCAM regulates the development and morphology of intestinal epithelium via controlling the EGFR pathway

Zili Leia,d( ), Ya Niea,b,d, Lulu Liua,d, Yanhong Yangc,d( ), Xuan Liua,d, Guibin Chena, Yunjuan Wangc, Wanwan Liua, Qing Hua, Ting Lina, Jiao Guoa( )
Guangdong Metabolic Diseases Research Center of Integrated Chinese and Western Medicine, Guangdong Pharmaceutical University, Guangzhou, Guangdong 510006, China
School of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou, Guangdong 510006, China
The First Affiliated Hospital (The First Clinical Medical School), Guangdong Pharmaceutical University, Guangzhou, Guangdong 510080, China

d These authors contributed equally to this work.

Peer review under the responsibility of Chongqing Medical University.

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Genes & Diseases
Volume 13 Issue 5,
September 2026
DOI: 10.1016/j.gendis.2026.102072

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Cite this article:
Lei Z, Nie Y, Liu L, et al. Single-cell transcriptomics reveals EpCAM regulates the development and morphology of intestinal epithelium via controlling the EGFR pathway. Genes & Diseases, 2026, 13(5). https://doi.org/10.1016/j.gendis.2026.102072

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Received: 10 July 2025
Published: 09 February 2026
© 2026 The Authors.

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).