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Rapid Communication | Open Access

Human Gordon Holmes Syndrome modeling in mice reveals essential function of RNF216 ubiquitination in spermatogenesis and male fertility

Jeffrey M. Manna,b, Chao Weia, Xiaoyuan Yana, Huirong Xiec, Elena Y. Demirevac, Chen Chena,b,d( )
Department of Animal Science, Michigan State University, East Lansing, MI 48824, USA
Reproductive and Developmental Sciences Program, Michigan State University, East Lansing, MI 48824, USA
Transgenic and Genome Editing Facility, The Research Technology Support Facility, Institute for Quantitative Health Sciences & Engineering, Michigan State University, East Lansing, MI 48824, USA
Department of Obstetrics, Gynecology and Reproductive Biology, Michigan State University, Grand Rapids, MI 49503, USA

Peer review under the responsibility of Chongqing Medical University.

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Genes & Diseases
Volume 13 Issue 5,
September 2026
DOI: 10.1016/j.gendis.2026.102056

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Cite this article:
Mann JM, Wei C, Yan X, et al. Human Gordon Holmes Syndrome modeling in mice reveals essential function of RNF216 ubiquitination in spermatogenesis and male fertility. Genes & Diseases, 2026, 13(5). https://doi.org/10.1016/j.gendis.2026.102056

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Received: 11 November 2024
Published: 29 January 2026
© 2026 The Authors.

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).