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Rapid Communication | Open Access

SPP1 expression serves as a potential peripheral circulating biomarker for lung cancer prognostics and drives tumorigenesis

The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital, Zhengzhou, Henan 450008, China
Henan Key Laboratory of Molecular Pathology, Zhengzhou, Henan 450008, China
The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450001, China

d Those authors contributed equally.

Peer review under the responsibility of Chongqing Medical University.

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Genes & Diseases
Volume 13 Issue 3,
May 2026
DOI: 10.1016/j.gendis.2025.101994

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Cite this article:
Zhang X-R, Sun F-L, Wei B, et al. SPP1 expression serves as a potential peripheral circulating biomarker for lung cancer prognostics and drives tumorigenesis. Genes & Diseases, 2026, 13(3). https://doi.org/10.1016/j.gendis.2025.101994

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Received: 10 November 2025
Published: 23 December 2025
© 2025 The Authors.

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).