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Rapid Communication | Open Access

Variants in ARHGAP21, encoding a Rho GTPase-activating protein, are associated with focal epilepsy and neurodevelopmental disorders

Zilong Yea,f, Bingmei Lia,f, Longshan Xieb,f, Lingxia Feic, Xinguo Lud, Yunhua Hea, Jie Wanga, Yongjun Chene, Weiping Liaoa, Yiwu Shia( )
Department of Neurology, Institute of Neuroscience, Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and the Ministry of Education of China, The Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong 510260, China
Foshan First People's Hospital, Foshan, Guangdong 528000, China
Guangdong 999 Brain Hospital, Guangzhou, Guangdong 510510, China
Shenzhen Children's Hospital, Shenzhen, Guangdong 518026, China
The Affiliated Nanhua Hospital, Department of Neurology, Hengyang Medical School, University of South China, Hengyang, Hunan 421002, China

f These authors contributed equally to the manuscript.

Peer review under the responsibility of Chongqing Medical University.

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Genes & Diseases
Volume 13 Issue 5,
September 2026
DOI: 10.1016/j.gendis.2025.101988

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Cite this article:
Ye Z, Li B, Xie L, et al. Variants in ARHGAP21, encoding a Rho GTPase-activating protein, are associated with focal epilepsy and neurodevelopmental disorders. Genes & Diseases, 2026, 13(5). https://doi.org/10.1016/j.gendis.2025.101988

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Received: 02 June 2025
Published: 15 December 2025
© 2025 The Authors.

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).