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Rapid Communication | Open Access

MSC-EVs alleviate osteoarthritic joint pain and degeneration by suppressing IL-1β/NGF signaling

Kristeen Ye Wen Teoa, Chengming Wena, Raymond Chung Wen Wongb, Wei Seong Toha,b,c ( )
Department of Orthopaedic Surgery, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119228, Singapore
Faculty of Dentistry, National University of Singapore, Singapore 119085, Singapore
Tissue Engineering Program, Life Sciences Institute, National University of Singapore, Singapore 117510, Singapore

Peer review under responsibility of Chongqing Medical University.

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Genes & Diseases
Volume 13 Issue 3,
May 2026
DOI: 10.1016/j.gendis.2025.101981

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Cite this article:
Teo KYW, Wen C, Wong RCW, et al. MSC-EVs alleviate osteoarthritic joint pain and degeneration by suppressing IL-1β/NGF signaling. Genes & Diseases, 2026, 13(3). https://doi.org/10.1016/j.gendis.2025.101981

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Received: 26 June 2025
Published: 11 December 2025
© 2025 The Authors.

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).