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Review Article | Open Access

Obesity accelerates aging: Mechanisms and therapeutic implications

Rui Zhanga,c, Linlin Liub,c, Xiaoman Shia,c, Yanming Rena( )
Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China
The First College of Clinical Medicine, Chongqing Medical University, Chongqing 400016, China

c These authors contributed equally to this work.

Peer review under the responsibility of Chongqing Medical University.

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Abstract

Global aging is increasing, and both aging and age-related diseases have emerged as significant public health challenges. According to previous literature, aging is characterized by multiple hallmarks, such as systemic inflammation, telomere depletion, mitochondrial dysfunction, and others. Obesity is a chronic and complex disease. Notably, obesity can accelerate the aging process and shares several similar features with aging. Therefore, this review systematically summarizes the relationship between obesity and aging, and discusses the great potential of anti-obesity therapies in combating aging and aging-related diseases.

Keywords

AgingAging-related diseasesAnti-obesity therapiesObesityUnderlying mechanisms

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Genes & Diseases
Volume 13 Issue 5,
September 2026
DOI: 10.1016/j.gendis.2025.101980

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Review Status: {{reviewData.commendedNum}} Commended , {{reviewData.revisionRequiredNum}} Revision Required , {{reviewData.notCommendedNum}} Not Commended Under Peer Review

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Cite this article:
Zhang R, Liu L, Shi X, et al. Obesity accelerates aging: Mechanisms and therapeutic implications. Genes & Diseases, 2026, 13(5). https://doi.org/10.1016/j.gendis.2025.101980

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Received: 01 September 2025
Revised: 08 October 2025
Accepted: 28 October 2025
Published: 11 December 2025
© 2025 The Authors.

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).