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Rapid Communication | Open Access

Ammonia-induced cell death patterns in glioblastoma: Immune landscape, prognostic signature, and therapeutic target identification

Sheng-Qi Hua,b,c,f, Jing Wangb,c,f, Jing Wangd,f, Chun Zengc,e( ), Rudong Chena( )
Department of Neurosurgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China
Beijing Neurosurgical Institute, Capital Medical University, Beijing 100070, China
Department of Neurosurgery, Beijing TianTan Hospital, Capital Medical University, Beijing 100070, China
Department of Neurosurgery, Peking University International Hospital, Beijing 100070, China
China National Clinical Research Center for Neurological Diseases, Beijing 100070, China

f These authors contribute equally to this work.

Peer review under the responsibility of Chongqing Medical University.

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Genes & Diseases
Volume 13 Issue 5,
September 2026
DOI: 10.1016/j.gendis.2025.101979

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Cite this article:
Hu S-Q, Wang J, Wang J, et al. Ammonia-induced cell death patterns in glioblastoma: Immune landscape, prognostic signature, and therapeutic target identification. Genes & Diseases, 2026, 13(5). https://doi.org/10.1016/j.gendis.2025.101979

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Received: 22 June 2025
Published: 12 December 2025
© 2025 The Authors.

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).