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Rapid Communication | Open Access

Loss of minichromosome maintenance 4 leads to early renal dysplasia and cystogenesis outcomes

Jing Huanga,b,c, Hui-Ling Xiangc, Qian Yuanc, Chun Zhangc, Xian-Fang Mengd( )
Department of Geriatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, China
Key Laboratory of Vascular Aging, Ministry of Education, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, China
Department of Nephrology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, China
Department of Neurobiology, Institute of Brain Research, School of Basic Medical Sciences, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China

Peer review under the responsibility of Chongqing Medical University.

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Genes & Diseases
Volume 13 Issue 5,
September 2026
DOI: 10.1016/j.gendis.2025.101968

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Cite this article:
Huang J, Xiang H-L, Yuan Q, et al. Loss of minichromosome maintenance 4 leads to early renal dysplasia and cystogenesis outcomes. Genes & Diseases, 2026, 13(5). https://doi.org/10.1016/j.gendis.2025.101968

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Received: 28 March 2025
Published: 08 December 2025
© 2025 The Authors.

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).