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Rapid Communication | Open Access

Integrative pan-cancer analysis identifies CCHCR1 as a prognostic biomarker and therapeutic target driving EMT in hepatocellular carcinoma via PI3K/AKT activation

Shuting Huanga,d, Wanqiu Lia,d, Kaifang Wanga,b, Yu Caia, Lirui Qianc, Yiran Liuc, Feng Gaoc, Tong Fanga, Kin Yip Tamb( ), Ou Shaa( )
School of Basic Medical Sciences, Shenzhen University Medical School, Shenzhen, Guangdong 518000, China
Faculty of Health Sciences, University of Macau, Taipa, Macau SAR 999078, China
School of Dentistry, Shenzhen University Medical School, Shenzhen, Guangdong 518000, China

d These authors contributed equally to this work.

Peer review under the responsibility of Chongqing Medical University.

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Genes & Diseases
Volume 13 Issue 5,
September 2026
DOI: 10.1016/j.gendis.2025.101960

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Cite this article:
Huang S, Li W, Wang K, et al. Integrative pan-cancer analysis identifies CCHCR1 as a prognostic biomarker and therapeutic target driving EMT in hepatocellular carcinoma via PI3K/AKT activation. Genes & Diseases, 2026, 13(5). https://doi.org/10.1016/j.gendis.2025.101960

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Received: 05 August 2025
Published: 28 November 2025
© 2025 The Authors.

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).