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Rapid Communication | Open Access

UCH-L1 down-regulates HER2 expression and increases lapatinib sensitivity by interacting with HSP90 in HER2-positive breast cancer

Min Zhenga,b,i, Xisha Chenf,g,h,i, Wenqiang Gana,b, Lei Houe, Zhongmei Zhoud, Ceshi Chena,b,c,d( ), Zhenzhen Liue( ), Yan Chengf,g( )
Yunnan Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650201, China
Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming, Yunnan 650204, China
The Third Affiliated Hospital, Kunming Medical University, Kunming, Yunnan 650118, China
Academy of Biomedical Engineering, Kunming Medical University, Kunming, Yunnan 650500, China
Department of Breast Disease, Henan Breast Cancer Center, The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital, Zhengzhou, Henan 450008, China
Department of Pharmacy, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China
Hunan Provincial Engineering Research Centre of Translational Medicine and Innovative Drug, Changsha, Hunan 410011, China
Cancer Research Institute, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan 421001, China

i These authors contributed equally.

Peer review under the responsibility of Chongqing Medical University.

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Genes & Diseases
Volume 13 Issue 4,
July 2026
DOI: 10.1016/j.gendis.2025.101952

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Cite this article:
Zheng M, Chen X, Gan W, et al. UCH-L1 down-regulates HER2 expression and increases lapatinib sensitivity by interacting with HSP90 in HER2-positive breast cancer. Genes & Diseases, 2026, 13(4). https://doi.org/10.1016/j.gendis.2025.101952

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Received: 25 February 2025
Published: 24 November 2025
© 2025 The Authors.

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).