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Rapid Communication | Open Access

Decoding age-stratified mutational landscapes in CNS lymphoma via genomic and survival profiling for precision oncology

Jiawen Chena,f, Hongwei Liub,c,f, Qisheng Tanga,f, Huihui Chaia,d, Peng Wanga, Ruize Zhua, Tong Chene, Tianwen Lia( ), Zhifeng Shia( )
Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, 200040, China
Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China
Hunan International Scientific and Technological Cooperation Base of Brain Tumor Research, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China
The National Key Clinic Specialty, The Engineering Technology Research Center of Education Ministry of China, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration, Department of Neurosurgery, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, 510282, China
Department of Hematology, Huashan Hospital, Fudan University, Shanghai, 200040, China

f These authors contributed equally.

Peer review under the responsibility of Chongqing Medical University.

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Genes & Diseases
Volume 13 Issue 5,
September 2026
DOI: 10.1016/j.gendis.2025.101934

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Cite this article:
Chen J, Liu H, Tang Q, et al. Decoding age-stratified mutational landscapes in CNS lymphoma via genomic and survival profiling for precision oncology. Genes & Diseases, 2026, 13(5). https://doi.org/10.1016/j.gendis.2025.101934

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Received: 30 July 2025
Published: 17 November 2025
© 2025 The Authors.

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).