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Rapid Communication | Open Access

Human induced pluripotent stem cell-derived microglia with 1q21.1 deletion and duplication exhibit aberrant inflammatory response

Tanya Singha,b, Kubra Trabzonlua,b, Aleksandra Spasovaa,b, Phil Stephensc, David E.J. Lindend,e, Marianne B.M. van den Breea,f, Michael J. Owena,d, Jeremy Halla,e, Ujjwal Neogig, Adrian J. Harwooda,b, Yasir Ahmed Syeda,b( )
Neuroscience and Mental Health Innovation Institute, Hadyn Ellis Building, Cardiff University, Cathays, Cardiff CF24 4HQ, UK
School of Bioscience, Cardiff University, The Sir Martin Evans Building, Museum Ave, Cardiff CF10 3AX, UK
School of Dentistry, Cardiff University, Cardiff CF14 4XY, UK
Mental Health and Neuroscience Institute (MHeNs), Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht 6229 ER, the Netherlands
Division of Psychological Medicine and Clinical Neurosciences (DPMCN), School of Medicine, Cardiff University, Cardiff CF14 4YS, UK
Centre for Neuropsychiatric Genetics and Genomics, Hadyn Ellis Building, School of Medicine, Cardiff University, Cardiff CF24 4HQ, UK
The Systems Virology Lab, Division of Clinical Microbiology, Department of Laboratory Medicine, Karolinska Institutet, Huddinge 141 52, Sweden

Peer review under the responsibility of Chongqing Medical University.

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Genes & Diseases
Volume 13 Issue 4,
July 2026
DOI: 10.1016/j.gendis.2025.101923

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Singh T, Trabzonlu K, Spasova A, et al. Human induced pluripotent stem cell-derived microglia with 1q21.1 deletion and duplication exhibit aberrant inflammatory response. Genes & Diseases, 2026, 13(4). https://doi.org/10.1016/j.gendis.2025.101923

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Received: 11 March 2025
Published: 06 November 2025
© 2025 The Authors.

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).