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Rapid Communication | Open Access

NLRP3 deficiency reprograms hepatic glucose metabolism but fails to ameliorate hepatic inflammation and fibrosis in the MCD model

Yong Zoua,b,d, Xiaowen Wua,b,d, Jingyi Wanga,b,d, Jie Xiac, Sen Zhanga,b, Shuzhe Dinga,b, Weina Liua,b( ), Zhengtang Qia,b( )
Key Laboratory of Adolescent Health Assessment and Exercise Intervention of the Ministry of Education, East China Normal University, Shanghai 200241, China
College of Physical Education and Health, East China Normal University, Shanghai 200241, China
Department of Physical Education, Shanghai Jiao Tong University, Shanghai 200240, China

d These authors contributed equally to this work.

Peer review under the responsibility of Chongqing Medical University.

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Genes & Diseases
Volume 13 Issue 5,
September 2026
DOI: 10.1016/j.gendis.2025.101921

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Cite this article:
Zou Y, Wu X, Wang J, et al. NLRP3 deficiency reprograms hepatic glucose metabolism but fails to ameliorate hepatic inflammation and fibrosis in the MCD model. Genes & Diseases, 2026, 13(5). https://doi.org/10.1016/j.gendis.2025.101921

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Received: 07 June 2025
Published: 06 November 2025
© 2025 The Authors.

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).