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Rapid Communication | Open Access

The oncogenic role of CCDC178 in intrahepatic cholangiocarcinoma through LGR4-dependent signaling and immune modulation

Yunlu Jiaa,g( ), Yanli Wangc,g, Yongxia Chend,g, Dayong Zhenge, Wenguang Fuf, Xiaochen Zhanga, Yunkun Lub( ), Jian Ruana,e,f( )
Department of Medical Oncology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310003, China
Department of General Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310000, China
Department of Pathology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310003, China
Department of Surgical Oncology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310020, China
Cancer Center, Integrated Hospital of Traditional Chinese Medicine, Southern Medical University, Guangzhou, Guangdong 510515, China
Department of Hepatobiliary Surgery, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan 646000, China

g These authors contributed equally to this work.

Peer review under the responsibility of Chongqing Medical University.

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Genes & Diseases
Volume 13 Issue 5,
September 2026
DOI: 10.1016/j.gendis.2025.101910

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Cite this article:
Jia Y, Wang Y, Chen Y, et al. The oncogenic role of CCDC178 in intrahepatic cholangiocarcinoma through LGR4-dependent signaling and immune modulation. Genes & Diseases, 2026, 13(5). https://doi.org/10.1016/j.gendis.2025.101910

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Received: 24 July 2025
Published: 28 October 2025
© 2025 The Authors.

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).