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Rapid Communication | Open Access

Circulating tumor DNA predicts tumor recurrence in early-stage breast cancer: A meta-analysis

Luke F. Moata,e, John G. Mayera,b,e, David S. Puthoffc,e, Adam M. Bissonnettea,d, Abdul R. Shourc, Scott J. Hebbringa, Adedayo A. Onitiloc( ), Zhi Wena( )
Center for Precision Medicine Research, Sanford-Marshfield Clinic Research Institute, Marshfield Clinic Health System, Marshfield, WI 54449, USA
Office of Research Computing and Analytics, Sanford-Marshfield Clinic Research Institute, Marshfield, WI 54449, USA
Cancer Care and Research Center, Sanford-Marshfield Clinic Research Institute, Marshfield Clinic Health System, Marshfield, WI 54449, USA
Integrated Research & Development Lab, Sanford-Marshfield Clinic Research Institute, Marshfield Clinic Health System, Marshfield, WI 54449, USA

e These authors contributed equally.

Peer review under the responsibility of Chongqing Medical University.

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Genes & Diseases
Volume 13 Issue 4,
July 2026
DOI: 10.1016/j.gendis.2025.101908

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Cite this article:
Moat LF, Mayer JG, Puthoff DS, et al. Circulating tumor DNA predicts tumor recurrence in early-stage breast cancer: A meta-analysis. Genes & Diseases, 2026, 13(4). https://doi.org/10.1016/j.gendis.2025.101908

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Received: 09 March 2025
Published: 30 October 2025
© 2025 The Authors.

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).