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Rapid Communication | Open Access

Immune patterns of the tumor microenvironment in PD-L1+ EGFR+ HNSCC patients received anti-PD-1 and EGFR-based neoadjuvant therapy

Yuan Zhia,b,c, Wenhao Rena,b, Shaoming Lia,b, Jingjing Zhenga,b, Jianzhong Songd, Ling Gaoa,b, Keqian Zhia,b( )
Department of Oral and Maxillofacial Reconstruction, The Affiliated Hospital of Qingdao University, Qingdao, Shandong 266555, China
Key Lab of Oral Clinical Medicine, The Affiliated Hospital of Qingdao University, Qingdao, Shandong 266555, China
Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology, Beijing 100083, China
Department of Oral and Maxillofacial Surgery, People's Hospital of Rizhao, Rizhao, Shandong 276827, China

Peer review under the responsibility of Chongqing Medical University.

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Genes & Diseases
Volume 13 Issue 4,
July 2026
DOI: 10.1016/j.gendis.2025.101902

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Cite this article:
Zhi Y, Ren W, Li S, et al. Immune patterns of the tumor microenvironment in PD-L1+ EGFR+ HNSCC patients received anti-PD-1 and EGFR-based neoadjuvant therapy. Genes & Diseases, 2026, 13(4). https://doi.org/10.1016/j.gendis.2025.101902

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Received: 07 January 2025
Published: 24 October 2025
© 2025 The Authors.

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).