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Rapid Communication | Open Access

Integrative analysis reveals the clinical utility of cancer-associated fibroblast-derived signature, and its implication for young-onset thyroid cancer

Shenglong Xua,e, Tianyao Chub,e, Hongyan Chenc,e, Jing Wangc,e, Yufei Wangd, Yaoyao Liangd, Xinlei Zhangc, Yan Zhaoa, Peng Zhangb( )
Department of Otolaryngology, Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China
Beijing Key Laboratory for Genetics of Birth Defects, Beijing Pediatric Research Institute, MOE Key Laboratory of Major Diseases in Children, Rare Disease Center, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing 100045, China
Beijing ClouDNA Technology Co., Ltd., Beijing 101407, China
Shanghai Institute of Immunology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China

e These authors contributed equally to this work.

Peer review under the responsibility of Chongqing Medical University.

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Genes & Diseases
Volume 13 Issue 5,
September 2026
DOI: 10.1016/j.gendis.2025.101882

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Cite this article:
Xu S, Chu T, Chen H, et al. Integrative analysis reveals the clinical utility of cancer-associated fibroblast-derived signature, and its implication for young-onset thyroid cancer. Genes & Diseases, 2026, 13(5). https://doi.org/10.1016/j.gendis.2025.101882

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Received: 08 June 2025
Published: 17 October 2025
© 2025 The Authors.

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).