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Rapid Communication | Open Access

Multi-omics Mendelian randomization combined with single-cell and spatial transcriptomics: Multidimensional validation of drug targets for osteoarthritis

Bo Yanga,e, Feng Lib,e, Jindong Caoa, Yuxuan Xiea, Yifeng Dab, Xuejun Yangb, Xiaodong Zhaoc, Wenhua Xingb( ), Jing Tiana,d( )
Center for Automated and Innovative Drug Discovery, College of Life Sciences, Northwest University, Xi’an, Shaanxi 710069, China
Department of Spinal Surgery Center Area A, The Second Affiliated Hospital of Inner Mongolia Medical University, Hohhot, Inner Mongolia 010000, China
Key Laboratory of Systems Biomedicine (Ministry of Education), Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai 200240, China
Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, School of Medicine, Northwest University, Xi’an, Shaanxi 710069, China

e These authors contributed equally to this work.

Peer review under the responsibility of Chongqing Medical University.

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Genes & Diseases
Volume 13 Issue 5,
September 2026
DOI: 10.1016/j.gendis.2025.101864

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Cite this article:
Yang B, Li F, Cao J, et al. Multi-omics Mendelian randomization combined with single-cell and spatial transcriptomics: Multidimensional validation of drug targets for osteoarthritis. Genes & Diseases, 2026, 13(5). https://doi.org/10.1016/j.gendis.2025.101864

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Received: 14 May 2025
Published: 23 September 2025
© 2025 The Authors.

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).