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Rapid Communication | Open Access

Arctigenin derivative (ARC-18) improved mitochondrial dysfunction and ameliorated frataxin deficiency symptoms via PGC-1α signaling

Qichao Gonga,b,h, Xiao Hanb,c,h, Tiansu Liub,d,h, Bocheng Xiongb, Bingge Zhangb, Yongmei Xiee, Huali Wanf, Tahir Alia,g( ), Xifei Yangb( ), Shupeng Lia,g( )
State Key Laboratory of Chemical Oncogenomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen, Guangdong 518055, China
Shenzhen Key Laboratory of Modern Toxicology, Shenzhen Medical Key Discipline of Health Toxicology (2020–2024), Shenzhen Center for Disease Control and Prevention, Shenzhen, Guangdong 518055, China
Department of Toxicology, School of Public Health, Shanxi Medical University, Taiyuan, Shanxi 030001, China
School of Public Health, Key Laboratory of Environmental Pollution Monitoring and Disease Control, Ministry of Education, Guizhou Medical University, Guiyang, Guizhou 561113, China
State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, and Collaborative Innovation Center of Biotherapy, Chengdu, Sichuan 610041, China
Department of Laboratory Medicine, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, Guangdong 510000, China
Shenzhen Bay Laboratory, Shenzhen, Guangdong 518055, China

h These authors contributed equally to this work.

Peer review under the responsibility of Chongqing Medical University.

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Genes & Diseases
Volume 13 Issue 4,
July 2026
DOI: 10.1016/j.gendis.2025.101838

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Cite this article:
Gong Q, Han X, Liu T, et al. Arctigenin derivative (ARC-18) improved mitochondrial dysfunction and ameliorated frataxin deficiency symptoms via PGC-1α signaling. Genes & Diseases, 2026, 13(4). https://doi.org/10.1016/j.gendis.2025.101838

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Received: 14 March 2025
Published: 01 September 2025
© 2025 The Authors.

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).