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Rapid Communication | Open Access

Identification of a novel prognostic gene signature associated with therapeutic resistance in hepatocellular carcinoma

Siliang Wanga,g( ), Shuangshuang Wangb,g, Xu Wangc,g, Yuxiang Sund, Xiao Dua, Dan Hana, Huanyu Nia, Yun Zhua, Huilian Shie( ), Zhaocong Yangf( )
Department of Pharmacy, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, Jiangsu 210000, China
Department of Pathology, Jiangsu Province Hospital of Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210029, China
Jiangsu Center for the Collaboration and Innovation of Cancer Biotherapy, Cancer Institute, Xuzhou Medical University, Xuzhou, Jiangsu 221000, China
Institute of Translational Medicine, Medical College, Yangzhou University, Yangzhou, Jiangsu 225009, China
Department of Infectious Diseases, Jiangsu Province Hospital of Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210029, China
Department of Cardiothoracic Surgery, Children’s Hospital of Nanjing Medical University, Nanjing, Jiangsu 210008, China

g These authors contributed equally to this work.

Peer review under the responsibility of Chongqing Medical University.

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Genes & Diseases
Volume 13 Issue 4,
July 2026
DOI: 10.1016/j.gendis.2025.101837

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Cite this article:
Wang S, Wang S, Wang X, et al. Identification of a novel prognostic gene signature associated with therapeutic resistance in hepatocellular carcinoma. Genes & Diseases, 2026, 13(4). https://doi.org/10.1016/j.gendis.2025.101837

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Received: 01 April 2025
Published: 30 August 2025
© 2025 The Authors.

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).