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Rapid Communication | Open Access

SF3B1K700E-driven transcriptional alterations in hematopoietic progenitors underlie blood cancer pathophysiology

Mengzhu Xuea, Jianhong Anb,c,d, Erqiang Hub,c,d, Wenjun Denge( ), Shanye Yinb,c,d( )
Innovation Center for AI and Drug Discovery, School of Pharmacy, East China Normal University, Shanghai 200062, China
Department of Pathology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
Einstein Pathology Single-Cell & Bioinformatics Laboratory, Bronx, NY 10461, USA
Montefiore Einstein Comprehensive Cancer Center, Albert Einstein College of Medicine, Bronx, NY 10461, USA
Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA

Peer review under the responsibility of Chongqing Medical University.

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Genes & Diseases
Volume 13 Issue 4,
July 2026
DOI: 10.1016/j.gendis.2025.101775

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Cite this article:
Xue M, An J, Hu E, et al. SF3B1K700E-driven transcriptional alterations in hematopoietic progenitors underlie blood cancer pathophysiology. Genes & Diseases, 2026, 13(4). https://doi.org/10.1016/j.gendis.2025.101775

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Received: 24 March 2025
Published: 15 July 2025
© 2025 The Authors.

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).