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Review Article | Open Access

The roles of cell cycle proteins in regulating the tumor immune microenvironment

Qingbo Zhu, Xiaoli Wei, Ziting Qu, Lili Lu, Yiyin Zhang( ), Hua Wang( )
Department of Oncology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230022, China

Peer review under responsibility of Chongqing Medical University.

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Abstract

Recent studies have shown that in addition to regulating the growth of tumor cells, cell cycle proteins can also regulate immune cells and factors in the tumor immune microenvironment (TIME), thus playing a role in regulating tumor immunity. This review summarizes the relevant mechanisms of cell cycle regulatory proteins in TIME regulation. The development of effective drugs against relevant therapeutic targets may be a hot research topic for the next generation of antitumor immunotherapy.

Keywords

Cell cycle proteinsMechanismsNegativePositiveTumor immune microenvironment

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Genes & Diseases
Volume 13 Issue 1,
January 2026
DOI: 10.1016/j.gendis.2025.101706

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Review Status: {{reviewData.commendedNum}} Commended , {{reviewData.revisionRequiredNum}} Revision Required , {{reviewData.notCommendedNum}} Not Commended Under Peer Review

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Cite this article:
Zhu Q, Wei X, Qu Z, et al. The roles of cell cycle proteins in regulating the tumor immune microenvironment. Genes & Diseases, 2026, 13(1). https://doi.org/10.1016/j.gendis.2025.101706

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Received: 10 August 2024
Revised: 04 March 2025
Accepted: 23 April 2025
Published: 04 June 2025
© 2025 The Authors.

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).