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Rapid Communication | Open Access

METTL3 promotes esophageal squamous cell carcinoma progression and reduces chemosensitivity to paclitaxel through the CASP9/BIRC3-dependent apoptosis pathway

Pengxiang Jia,c,1, Bo Wana,b,1( ), Minghui Gaoa, Shaohua Yina, Han Wua, Junjie Wanga, Yuting Mad, Weihua Xue,f( ), Minghua Wanga,f( )
Department of Biochemistry and Molecular Biology, Suzhou Medical College of Soochow University, Suzhou, Jiangsu 215123, China
School of Life Sciences, Suzhou Medical College of Soochow University, Suzhou, Jiangsu 215123, China
Suzhou Ruihua Orthopedic Hospital, Suzhou, Jiangsu 215104, China
CAS Key Lab of Bio-Medical Diagnostics, Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, Suzhou, Jiangsu 215163, China
Department of Thoracic and Cardiac Surgery, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215004, China
State Key Laboratory of Chemical Oncogenomics, Key Laboratory of Chemical Genomics, Peking University Shenzhen Graduate School, Shenzhen, Guangdong 518055, China

1 These authors contributed equally to this work.

Peer review under responsibility of Chongqing Medical University.

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Genes & Diseases
Volume 13 Issue 1,
January 2026
DOI: 10.1016/j.gendis.2025.101693

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Ji P, Wan B, Gao M, et al. METTL3 promotes esophageal squamous cell carcinoma progression and reduces chemosensitivity to paclitaxel through the CASP9/BIRC3-dependent apoptosis pathway. Genes & Diseases, 2026, 13(1). https://doi.org/10.1016/j.gendis.2025.101693

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Received: 07 July 2024
Published: 27 May 2025
© 2025 The Authors.

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).