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Review Article | Open Access

Circular RNAs in hepatitis B virus-induced hepatocellular carcinoma: A comprehensive review and recent advances

Wenjun Quana, Kizito Eneye Belloa,b, Rafidah Hanim Shuebc,d, Nazri Mustaffaa,e( )
Department of Medicine, School of Medical Sciences, Universiti Sains Malaysia, Health Campus, Kubang Kerian, Kelantan 16150, Malaysia
Department of Microbiology, Faculty of Natural Science, Kogi State University (Prince Abubakar Audu University), Anyigba, Kogi State 1008, Nigeria
Department of Medical Microbiology and Parasitology, School of Medical Sciences, Universiti Sains Malaysia, Health Campus, Kubang Kerian, Kelantan 16150, Malaysia
Institute for Research in Molecular Medicine (INFORMM), Universiti Sains Malaysia, Kubang Kerian, Kelantan 16150, Malaysia
Hospital Universiti Sains Malaysia, Kubang Kerian, Kelantan 16150, Malaysia

Peer review under the responsibility of the Genes & Diseases Editorial Office, in alliance with the Association of Chinese Americans in Cancer Research (ACACR, Baltimore, MD, USA)

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Abstract

Circular RNAs (circRNAs) are a class of stable and versatile non-coding RNAs that are pivotal in the occurrence and development of some diseases, particularly tumors. Hepatitis B virus (HBV)-induced hepatocellular carcinoma (HCC) is a liver disease with substantial global impact. Despite efforts towards adequate management, the survival of patients with HBV-induced HCC has been consistently low. circRNAs regulate various physiological activities of HBV-induced HCC. This review aims to elucidate the biogenesis of circRNAs and the pathophysiology of HBV-induced HCC and comprehensively analyze the applications of circRNAs in oncology and therapeutics. In addition, this review summarizes past research achievements on circRNAs in HBV-induced HCC. Finally, the limitations of existing methodologies and circRNA research in HBV-induced HCC have been discussed to provide a blueprint for future investigations.

Keywords

BiomarkercircRNAHepatitis B virusHepatocellular carcinomaTherapy

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Genes & Diseases
Volume 12 Issue 5,
September 2025
Article number: 101605
DOI: 10.1016/j.gendis.2025.101605

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Cite this article:
Quan W, Bello KE, Shueb RH, et al. Circular RNAs in hepatitis B virus-induced hepatocellular carcinoma: A comprehensive review and recent advances. Genes & Diseases, 2025, 12(5): 101605. https://doi.org/10.1016/j.gendis.2025.101605

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Received: 26 July 2024
Revised: 24 December 2024
Accepted: 25 January 2025
Published: 18 March 2025
© 2025 The Authors.

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).