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Rapid Communication | Open Access

Electrophysiological and histological study reveals hidden subclinical haploinsufficiency of Otof

Kyu-Hee Hana,1, Yehree Kimb,1,§, Kwon Woo Kangc,1, Ju Ang Kimb,1, Yonghee Ohd, Min Young Kimb, Jin Hee Hanb, Bong Jik Kime, Eunyoung Yic( ), Byung Yoon Choib( )
Department of Otorhinolaryngology, National Medical Center, Seoul 04564, South Korea
Department of Otorhinolaryngology, Seoul National University Bundang Hospital, Seongnam 13620, South Korea
College of Pharmacy and Natural Medicine Research Institute, Mokpo National University, Muan 58554, South Korea
Department of Otolaryngology, HNS and Communicative Disorders, School of Medicine, University of Louisville, Louisville, KY 40202, USA
Chungnam National University College of Medicine, Chungnam National University Sejong Hospital, Sejong 30099, South Korea

Peer review under the responsibility of Chongqing Medical University.

1 These authors contributed equally to this work.

§ Current address: Eaton-Peabody Laboratory, Massachusetts Eye and Ear Infirmary, Boston, MA 02114, USA.

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Genes & Diseases
Volume 13 Issue 2,
March 2026
DOI: 10.1016/j.gendis.2025.101600

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Cite this article:
Han K-H, Kim Y, Kang KW, et al. Electrophysiological and histological study reveals hidden subclinical haploinsufficiency of Otof. Genes & Diseases, 2026, 13(2). https://doi.org/10.1016/j.gendis.2025.101600

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Received: 22 August 2024
Published: 13 March 2025
© 2025 The Authors.

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).