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Rapid Communication | Open Access

Otof gene transfer in DFNB9 mice carrying human founder non-truncating alleles

Yehree Kima,i,1, Yoojin Chungb,c,1, Ju Ang Kima,1, Kyu Hee Hand, Kwon Woo Kange, Ngoc-Trinh Trana, Min Young Kima, Eunyoung Yie, Sangyong Jungf, Bong Jik Kimg,h, Quynh-Anh Artinianb, Seth D. Koehlerb,c, Ning Panb,c, Tyler M. Gibsonb, Lars Beckerb,c, Joseph W. Goodliffeb,c, Molly Kalkerb, Madeline Barnesb, Luke A. Shaheenb,c, Meghan C. Drummondc, Vassili Valayannopoulosb,c, Byung Yoon Choia( )
Department of Otorhinolaryngology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam 13620, South Korea
Decibel Therapeutics, Inc., Boston, MA 02215, United States
Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, United States
Department of Otorhinolaryngology, National Medical Center, Seoul 04564, South Korea
College of Pharmacy and Natural Medicine Research Institute, Mokpo National University, Muan 58554, South Korea
Department of Medical Science, College of Medicine, CHA University, Seongnam 13488, South Korea
Department of Otorhinolaryngology, Chungnam National University School of Medicine, Chungnam National University Sejong Hospital, Sejong 30099, South Korea
Brain Research Institute, Chungnam National University College of Medicine, Daejeon 35015, South Korea
Eaton-Peabody Laboratory, Massachusetts Eye and Ear Infirmary, Boston, MA 02114, United States

1 These authors contributed equally to this work.

Peer review under the responsibility of the Genes & Diseases Editorial Office, in alliance with the Association of Chinese Americans in Cancer Research (ACACR, Baltimore, MD, USA)

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Genes & Diseases
Volume 12 Issue 5,
September 2025
Article number: 101590
DOI: 10.1016/j.gendis.2025.101590

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Cite this article:
Kim Y, Chung Y, Kim JA, et al. Otof gene transfer in DFNB9 mice carrying human founder non-truncating alleles. Genes & Diseases, 2025, 12(5): 101590. https://doi.org/10.1016/j.gendis.2025.101590

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Received: 09 September 2024
Published: 06 March 2025
© 2025 The Authors.

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).