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Commentary | Open Access

Elucidating the pathogenesis of bladder cancer through single-cell chromatin accessibility and DNA methylation analysis

Yu Xiaoa,b,1, Lingao Jub,1, Gang Wangb,c,1, Wan Jinb,d, Hongwei Pengb, Zongning Zhoub, Mengxue Yub,c, Yi Zhangd,e, Kaiyu Qianb,c( ), Xinghuan Wanga,f,g( )
Department of Urology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei 430071, China
Department of Biological Repositories, Human Genetic Resources Preservation Center of Hubei Province, Zhongnan Hospital of Wuhan University, Wuhan, Hubei 430071, China
Hubei Key Laboratory of Urological Diseases, Laboratory of Precision Medicine, Zhongnan Hospital of Wuhan University, Wuhan, Hubei 430071, China
Euler Technology, ZGC Life Sciences Park, Beijing 102206, China
High Performance Computing Center, The Peking-Tsinghua College of Life Sciences, Peking University, Beijing 100091, China
Wuhan Research Center for Infectious Diseases and Cancer, Chinese Academy of Medical Sciences, Wuhan, Hubei 430071, China
Medical Research Institute, Frontier Science Center for Immunology and Metabolism, Taikang Center for Life and Medical Sciences, Wuhan University, Wuhan, Hubei 430071, China

1 These authors contributed equally to this work.

Peer review under the responsibility of the Genes & Diseases Editorial Office, in alliance with the Association of Chinese Americans in Cancer Research (ACACR, Baltimore, MD, USA)

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Genes & Diseases
Volume 12 Issue 5,
September 2025
Article number: 101578
DOI: 10.1016/j.gendis.2025.101578

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Cite this article:
Xiao Y, Ju L, Wang G, et al. Elucidating the pathogenesis of bladder cancer through single-cell chromatin accessibility and DNA methylation analysis. Genes & Diseases, 2025, 12(5): 101578. https://doi.org/10.1016/j.gendis.2025.101578

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Received: 22 October 2024
Revised: 31 December 2024
Accepted: 17 February 2025
Published: 03 March 2025
© 2025 The Authors.

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).