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Rapid Communication | Open Access

Multi-omics analysis of epigenetic dysregulation reveals clinical heterogeneity and evaluates the immunotherapeutic potential of lung adenocarcinoma

Yuqing Rena,1, Zaoqu Liub,1, Yi Yuea, Siyuan Wengc, Hongxia Jiaa, Jing Lia, Ping Lia, Chunya Lua, Xinwei Hanc( ), Guojun Zhanga( )
Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China
State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Department of Pathophysiology, Peking Union Medical College, Beijing 100730, China
Department of Interventional Radiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China

1 These authors contributed equally to this work and shared the first authorship.

Peer review under the responsibility of the Genes & Diseases Editorial Office, in alliance with the Association of Chinese Americans in Cancer Research (ACACR, Baltimore, MD, USA)

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Genes & Diseases
Volume 12 Issue 5,
September 2025
Article number: 101561
DOI: 10.1016/j.gendis.2025.101561

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Cite this article:
Ren Y, Liu Z, Yue Y, et al. Multi-omics analysis of epigenetic dysregulation reveals clinical heterogeneity and evaluates the immunotherapeutic potential of lung adenocarcinoma. Genes & Diseases, 2025, 12(5): 101561. https://doi.org/10.1016/j.gendis.2025.101561

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Received: 18 April 2024
Published: 20 February 2025
© 2025 The Authors.

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).