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Letter | Open Access

VEXAS syndrome caused by a UBA1 mutation is complicated by recurrent infections leading to hemophagocytic lymphohistiocytosis

Yu Tanga,b, Hongfei Cuia,b, Hongjun Zhaob,c,d,e, Hui Luob,c,d,e, Xiaoxia Zuob,c,d,e, Junjiao Wub,c,d,e( )
Aging Research Center, Department of Geriatrics, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China
National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China
Department of Rheumatology and Immunology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China
Provincial Clinical Research Center for Rheumatic and Immunologic Diseases, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China
Hunan Provincial Skin Immunization and Medical Center, Changsha, Hunan 410008, China

Peer review under the responsibility of the Genes & Diseases Editorial Office, in alliance with the Association of Chinese Americans in Cancer Research (ACACR, Baltimore, MD, USA).

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Genes & Diseases
Volume 12 Issue 5,
September 2025
Article number: 101540
DOI: 10.1016/j.gendis.2025.101540

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Cite this article:
Tang Y, Cui H, Zhao H, et al. VEXAS syndrome caused by a UBA1 mutation is complicated by recurrent infections leading to hemophagocytic lymphohistiocytosis. Genes & Diseases, 2025, 12(5): 101540. https://doi.org/10.1016/j.gendis.2025.101540

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Received: 23 October 2024
Published: 22 January 2025
© 2025 The Authors.

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).