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Review Article | Open Access

The epigenetic regulatory network of long noncoding RNAs in hepatocellular carcinoma

Zhaoqi Shia, Shengxi Jina, Xiaolong Liua, Mengting Jianga, Yifeng Fanga, Parikshit Asutosh Khadaroob, Hui Lina,c( ), Xiaoxiao Fana( )
Department of General Surgery, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310016, China
Neuropsychiatry & ECT Department, Royal Melbourne Hospital, Grattan Street Parkville, Melbourne, VIC 3052, Australia
College of Biomedical Engineering and Instrument Science, Zhejiang University, Hangzhou, Zhejiang 310027, China

Peer review under the responsibility of the Genes & Diseases Editorial Office, in alliance with the Association of Chinese Americans in Cancer Research (ACACR, Baltimore, MD, USA)

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Abstract

Long noncoding RNAs (lncRNAs) are endogenous noncoding RNAs exceeding 200 bases in length that are prevalent in malignant tumors and are closely associated with the onset and progression of hepatocellular carcinoma. The synthesis of lncRNAs exhibits similarities to that of protein-coding transcripts, which is regulated by epigenetic modifications. Recent research has highlighted the significant regulatory role of epigenetic modifications in the transcription of lncRNA genes in hepatocellular carcinoma. This review outlines the impact of epigenetic modifications, including DNA methylation, histone modification (methylation and acetylation), RNA modification, and microRNAs on the transcription of lncRNA genes in hepatocellular carcinoma and delves into the underlying mechanisms by summarizing how these lncRNA genes contribute to the development and progression of hepatocellular carcinoma.

Keywords

DNA methylationEpigeneticsHepatocellular carcinomaHistone modificationLong noncoding RNAMicroRNARNA methylation

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Genes & Diseases
Volume 12 Issue 5,
September 2025
Article number: 101534
DOI: 10.1016/j.gendis.2025.101534

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Review Status: {{reviewData.commendedNum}} Commended , {{reviewData.revisionRequiredNum}} Revision Required , {{reviewData.notCommendedNum}} Not Commended Under Peer Review

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Cite this article:
Shi Z, Jin S, Liu X, et al. The epigenetic regulatory network of long noncoding RNAs in hepatocellular carcinoma. Genes & Diseases, 2025, 12(5): 101534. https://doi.org/10.1016/j.gendis.2025.101534

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Received: 21 June 2024
Revised: 29 November 2024
Accepted: 18 December 2024
Published: 20 January 2025
© 2025 The Authors.

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).