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Rapid Communication | Open Access

In vivo consequences of varying degrees of OTOA alteration elucidated using knock-in mouse models and pseudogene contamination-free long-read sequencing

Ju Ang Kima,f,1, Bong Jik Kimb,c,1, Chung Leed, Go Hun Seoe, Hane Leee, Jin Hee Hanc,f, Ava Niazia, Joosang Parka, Byung Yoon Choif,2( ), Sungjin Parka,2( )
Department of Neurobiology, University of Utah, Salt Lake City, UT 84112, USA
Department of Otorhinolaryngology, Chungnam National University College of Medicine, Chungnam National University Sejong Hospital, Sejong 30099, South Korea
Brain Research Institute, Chungnam National University College of Medicine, Daejeon 35015, South Korea
Department of Pathology, Severance Hospital, Yonsei University College of Medicine, Seoul 03722, South Korea
3billion, Inc., Seoul 06193, South Korea
Department of Otorhinolaryngology–Head and Neck Surgery, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam 13620, South Korea

Peer review under the responsibility of the Genes & Diseases Editorial Office, in alliance with the Association of Chinese Americans in Cancer Research (ACACR, Baltimore, MD, USA).

1 These authors contributed equally to this work and shared the first authorship.

2 These corresponding authors contributed equally to this work and shared the senior authorship.

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Genes & Diseases
Volume 12 Issue 3,
May 2025
Article number: 101533
DOI: 10.1016/j.gendis.2025.101533

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Kim JA, Kim BJ, Lee C, et al. In vivo consequences of varying degrees of OTOA alteration elucidated using knock-in mouse models and pseudogene contamination-free long-read sequencing. Genes & Diseases, 2025, 12(3): 101533. https://doi.org/10.1016/j.gendis.2025.101533

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Received: 23 May 2024
Published: 18 January 2025
© 2025 The Authors.

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).