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Review Article | Open Access

The role of lncRNAs in AKI and CKD: Molecular mechanisms, biomarkers, and potential therapeutic targets

Minhui Zhenga, Zixuan Yanga, Lei Shia, Liyuan Zhaob,c, Kelan Liud( ), Naping Tanga( )
Shanghai Innostar Bio-Technology Co., Ltd., China State Institute of Pharmaceutical Industry, Shanghai 201203, China
Anhui University of Traditional Chinese Medicine, Hefei, Anhui 230000, China
Yangtze Delta Drug Advanced Research Institute, Yangtze Delta Pharmaceutical College, Nantong, Jiangsu 226133, China
Intensive Care Unit, Liyang People’s Hospital, Liyang, Jiangsu 213300, China

Peer review under the responsibility of the Genes & Diseases Editorial Office, in alliance with the Association of Chinese Americans in Cancer Research (ACACR, Baltimore, MD, USA).

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Abstract

Exosomes, a type of extracellular vesicle, are commonly found in different body fluids and are rich in nucleic acids (circRNA, lncRNAs, miRNAs, mRNAs, tRNAs, etc.), proteins, and lipids. They are involved in intercellular communication. lncRNAs are responsible for the modulation of gene expression, thus affecting the pathological process of kidney injury. This review summarizes the latest knowledge on the roles of exosome lncRNAs and circulating lncRNAs in the pathogenesis, biomarker discovery, and treatment of chronic kidney disease, renal fibrosis, and acute kidney injury, providing an overview of novel regulatory approaches and lncRNA delivery systems.

Keywords

Acute kidney injuryBiomarkerChronic kidney diseaseExosomelncRNARenal fibrosis

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Genes & Diseases
Volume 12 Issue 3,
May 2025
Article number: 101509
DOI: 10.1016/j.gendis.2024.101509

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Cite this article:
Zheng M, Yang Z, Shi L, et al. The role of lncRNAs in AKI and CKD: Molecular mechanisms, biomarkers, and potential therapeutic targets. Genes & Diseases, 2025, 12(3): 101509. https://doi.org/10.1016/j.gendis.2024.101509

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Received: 03 April 2023
Revised: 04 February 2024
Accepted: 02 November 2024
Published: 30 December 2024
© 2025 The Authors.

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).