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Rapid Communication | Open Access

RNA-seq identifies Amd1 as a regulator of hepatocyte proliferation via Skp2 during liver development and hepatocellular carcinoma progression in zebrafish

Ke Zhanga,e,1, Botong Lia,1, Zhiling Denga, Yong Donga, Yuanyuan Lib, Bingyu Chena, Mao Luc, Liyan Wanga, Xingdong Liub, Zhenhua Guod( ), Sizhou Huanga,b( )
Development and Regeneration Key Laboratory of Sichuan Province, Department of Anatomy and Histology and Embryology, School of Basic Medical Sciences, Chengdu Medical College, Chengdu, Sichuan 610500, China
Department of Neurology, The Second Affiliated Hospital of Chengdu Medical College, China National Nuclear Corporation 416 Hospital, Chengdu, Sichuan 610000, China
Department of Dermatovenereology, The First Affiliated Hospital of Chengdu Medical College, Chengdu, Sichuan 610500, China
Ministry of Education Key Laboratory of Child Development and Disorders, Key Laboratory of Pediatrics in Chongqing, CSTC2009CA5002, Chongqing International Science and Technology Cooperation Center for Child Development and Disorders, Children’s Hospital of Chongqing Medical University, Chongqing 400014, China
Central Hospital of Suining, Suining, Sichuan 629000, China

1 These authors contributed equally to this work and shared first authorship.

Peer review under the responsibility of the Genes & Diseases Editorial Office, in alliance with the Association of Chinese Americans in Cancer Research (ACACR, Baltimore, MD, USA).

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Genes & Diseases
Volume 12 Issue 5,
September 2025
Article number: 101486
DOI: 10.1016/j.gendis.2024.101486

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Zhang K, Li B, Deng Z, et al. RNA-seq identifies Amd1 as a regulator of hepatocyte proliferation via Skp2 during liver development and hepatocellular carcinoma progression in zebrafish. Genes & Diseases, 2025, 12(5): 101486. https://doi.org/10.1016/j.gendis.2024.101486

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Received: 03 August 2024
Published: 11 December 2024
© 2024 The Authors.

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).