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Rapid Communication | Open Access

Engrailed-1 inactivation leads to scarless skin wound healing through extracellular matrix remodeling

Ailing Haoa, Xiangyu Donga, Yannian Goua, Aohua Lia, Jiajia Lia, Han Xianga, Saidur Rahamana, Yi Zhub,c, Hui Zhangb,d, Wulin Youb,e, Guowei Shenb,f, Changqi Luob,g, Ou Meib,h, Xingye Wub,i, Lewis L. Shib, Russell R. Reidb,j, Tong-Chuan Heb,j, Jiaming Fana( )
Ministry of Education Key Laboratory of Diagnostic Medicine, Department of Clinical Biochemistry, College of Laboratory Medicine, Chongqing Medical University, Chongqing 400016, China
Molecular Oncology Laboratory, Department of Orthopaedic Surgery and Rehabilitation Medicine, The University of Chicago Medical Center, Chicago, IL 60637, USA
Department of Orthopaedic Surgery, Beijing Hospital, National Center of Gerontology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100005, China
The Breast Cancer Center, Chongqing University Cancer Hospital, Chongqing 400030, China
Department of Orthopaedic Surgery, Wuxi Hospital Affiliated to Nanjing University of Chinese Medicine, Wuxi, Jiangsu 214071, China
Department of Orthopaedic Surgery, BenQ Medical Center, The Affiliated BenQ Hospital of Nanjing Medical University, Nanjing, Jiangsu 210019, China
Department of Orthopaedic Surgery, Yibin Second People's Hospital, Affiliated with West China School of Medicine, Yibin, Sichuan 644000, China
Department of Orthopedics, Jiangxi Hospital of Traditional Chinese Medicine, Jiangxi University of Traditional Chinese Medicine, Nanchang, Jiangxi 330006, China
Department of Gastrointestinal Surgery, The First Affiliated Hospital of Chongqing, Medical University, Chongqing 400016, China
Laboratory of Craniofacial Biology and Development, Section of Plastic and Reconstructive Surgery, Department of Surgery, The University of Chicago Medical Center, Chicago, IL 60637, USA

Peer review under the responsibility of the Genes & Diseases Editorial Office, in alliance with the Association of Chinese Americans in Cancer Research (ACACR, Baltimore, MD, USA).

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Genes & Diseases
Volume 12 Issue 3,
May 2025
Article number: 101484
DOI: 10.1016/j.gendis.2024.101484

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Cite this article:
Hao A, Dong X, Gou Y, et al. Engrailed-1 inactivation leads to scarless skin wound healing through extracellular matrix remodeling. Genes & Diseases, 2025, 12(3): 101484. https://doi.org/10.1016/j.gendis.2024.101484

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Received: 03 August 2024
Published: 09 December 2024
© 2024 The Authors.

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).