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Review Article | Open Access

Epigenetic regulation of nuclear receptors: Implications for endocrine-related diseases and therapeutic strategies

Yixin Songa,1, Kexin Zhanga,1, Jingwen Zhanga, Qinying Lia, Na Huanga, Yujie Maa, Ningning Houa, Fang Hanb, Chengxia Kana( ), Xiaodong Suna( )
Department of Endocrinology and Metabolism, Clinical Research Center, Shandong Provincial Key Medical and Health Discipline of Endocrinology, Affiliated Hospital of Shandong Second Medical University, Weifang, Shandong 261031, China
Department of Pathology, Affiliated Hospital of Shandong Second Medical University, Weifang, Shandong 261031, China

Peer review under the responsibility of the Genes & Diseases Editorial Office, in alliance with the Association of Chinese Americans in Cancer Research (ACACR, Baltimore, MD, USA).

1 These authors contributed equally to this work and shared the first authorship.

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Abstract

The expression and function of the receptor are controlled by epigenetic changes, such as DNA methylation, histone modification, and noncoding RNAs. These modifications play a pivotal role in receptor activity and can lead to or exacerbate endocrine-related diseases. This review examines the epigenetic alterations of nuclear receptors and their significant impact on conditions such as diabetes, thyroid disorders, and endocrine-related tumors. It highlights current therapies targeting these epigenetic mechanisms, including gene editing, epigenetic drugs, and various other therapeutic approaches. This review offers fresh insight into the mechanisms of endocrine-associated disorders, highlighting the latest progress in the development of novel epigenetic therapies that can be used to address receptor–endocrine interactions.

Keywords

Androgen receptorBreast cancerDNA methylationEpigenetic modulationEstrogen receptorHistone modificationNuclear receptor

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Genes & Diseases
Volume 12 Issue 4,
July 2025
Article number: 101481
DOI: 10.1016/j.gendis.2024.101481

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Cite this article:
Song Y, Zhang K, Zhang J, et al. Epigenetic regulation of nuclear receptors: Implications for endocrine-related diseases and therapeutic strategies. Genes & Diseases, 2025, 12(4): 101481. https://doi.org/10.1016/j.gendis.2024.101481

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Received: 07 May 2024
Revised: 20 October 2024
Accepted: 03 November 2024
Published: 04 December 2024
© 2024 The Authors.

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).