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Review Article | Open Access

The role of RGS12 in tissue repair and human diseases

Min Jianga,b,1, Hongmei Lic,1, Qiong Zhangd, Tongtong Xue, Le Huangf, Jinghong Zhangb, Huiqing Yua,g( ), Junhui Zhanga,g( )
Department of Geriatric Oncology and Department of Palliative Care, Chongqing University Cancer Hospital, Chongqing 400030, China
Department of Plastic Surgery, State Key Laboratory of Trauma, Burns and Combined Injury, Southwest Hospital, The Third Military Medical University (Army Medical University), Chongqing 400038, China
Department of Oncology and Southwest Cancer Center, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing 400038, China
Institute of Burn Research, State Key Laboratory of Trauma, Burns and Combined Injury, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing 400038, China
General Department of Critical Care Medicine, Zhenjiang Traditional Chinese Medicine Hospital, Affiliated Hospital of Nanjing University of Traditional Chinese Medicine, Zhenjiang, Jiangsu 212003, China
Army 72nd Group Military Hospital, Huzhou, Zhejiang 313000, China
Chongqing Key Laboratory of Translational Research for Cancer Metastasis and Individualized Treatment, Chongqing University Cancer Hospital, Chongqing 400030, China

Peer review under the responsibility of the Genes & Diseases Editorial Office, in alliance with the Association of Chinese Americans in Cancer Research (ACACR, Baltimore, MD, USA).

1 These authors contributed equally to this work.

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Abstract

Regulator of G protein signaling 12 (RGS12) belongs to the superfamily of RGS proteins defined by a conserved RGS domain that canonically binds and deactivates heterotrimeric G-proteins. As the largest family member, RGS12 is widely expressed in many cells and tissues. In the past few decades, it has been found that RGS12 affects the activity of various cells in the human body, participates in many physiological and pathological processes, and plays an important role in the pathogenesis of many diseases. Here, we set out to comprehensively review the role of RGS12 in human diseases and its mechanisms, highlighting the possibility of RGS12 as a therapeutic target for the treatment of human diseases.

Keywords

CancerNervous disordersOsteoporosisRGS12Tissue repair

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Genes & Diseases
Volume 12 Issue 4,
July 2025
Article number: 101480
DOI: 10.1016/j.gendis.2024.101480

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Cite this article:
Jiang M, Li H, Zhang Q, et al. The role of RGS12 in tissue repair and human diseases. Genes & Diseases, 2025, 12(4): 101480. https://doi.org/10.1016/j.gendis.2024.101480

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Received: 05 February 2024
Revised: 05 August 2024
Accepted: 02 November 2024
Published: 04 December 2024
© 2024 The Authors.

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).