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Rapid Communication | Open Access

lncRNA POU3F3 promotes osteosarcoma progression through GPX4-modulated ferroptosis by interaction with IGF2BP2 to facilitate NRF2 mRNA stability

Suyang Xua,b,1, Yingjie Zhouc,1, Ma Wana,b, Yikang Bia,b, Pengcheng Liua,b, Zixiang Lia,b, Yafeng Xua,b, Hao Fanga,b, Hai Hua,b, Chongshan Yangd( ), Shenghui Lana,b( )
Department of Orthopaedics, The Eighth People’s Hospital, Jiangsu University, Shanghai 200235, China
Department of Orthopaedics, Xuhui Branch of The Sixth People’s Hospital, Shanghai Jiao Tong University, Shanghai 200233, China
Department of Anesthesiology, Dongfang Hospital of Beijing University of Chinese Medicine, Beijing 100078, China
Department of Orthopaedics, Suzhou Wujiang District Hospital of Traditional Chinese Medicine (Suzhou Wujiang District Second People’s Hospital), Suzhou 215000, China

Peer review under responsibility of Chongqing Medical University.

1 These authors contributed equally to this work.

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Genes & Diseases
Volume 12 Issue 5,
September 2025
Article number: 101439
DOI: 10.1016/j.gendis.2024.101439

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Xu S, Zhou Y, Wan M, et al. lncRNA POU3F3 promotes osteosarcoma progression through GPX4-modulated ferroptosis by interaction with IGF2BP2 to facilitate NRF2 mRNA stability. Genes & Diseases, 2025, 12(5): 101439. https://doi.org/10.1016/j.gendis.2024.101439

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Received: 07 June 2024
Published: 12 October 2024
© 2024 The Authors.

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).