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Rapid Communication | Open Access

Shikonin is a novel antagonist of prostaglandin E2 receptor 4 that targets myeloid-derived suppressor cells

Yang Wanga,1( ), Naijipu Abuduainib,1, Wenjuan Liuc,1, Yuanjun Songd, Zunping Kee, Xilong Wanga, Wei Jiaoa, Si Chenc, Xianhua Linc, Weiwei Yuc, Weiqiang Luc, Bo Fengb( ), Jiacheng Hef( )
Department of Urology, The Fifth People’s Hospital of Shanghai, Fudan University, Shanghai 200240, China
Department of General Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200020, China
Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai 200241, China
Shanghai Municipal Health Commission, Shanghai 200125, China
Department of Gerontology, The Fifth People’s Hospital of Shanghai, Fudan University, Shanghai 200240, China
Joint Center for Translational Medicine, Shanghai Fifth People’s Hospital, Fudan University and School of Life Science, East China Normal University, Shanghai 200240, China

1 These authors contributed equally to this work.

Peer review under the responsibility of the Genes & Diseases Editorial Office, in alliance with the Association of Chinese Americans in Cancer Research (ACACR, Baltimore, MD, USA).

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Genes & Diseases
Volume 12 Issue 3,
May 2025
Article number: 101356
DOI: 10.1016/j.gendis.2024.101356

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Cite this article:
Wang Y, Abuduaini N, Liu W, et al. Shikonin is a novel antagonist of prostaglandin E2 receptor 4 that targets myeloid-derived suppressor cells. Genes & Diseases, 2025, 12(3): 101356. https://doi.org/10.1016/j.gendis.2024.101356

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Received: 28 April 2024
Published: 20 June 2024
© 2024 The Authors.

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).