AI Chat Paper
Note: Please note that the following content is generated by AMiner AI. SciOpen does not take any responsibility related to this content.
{{lang === 'zh_CN' ? '文章概述' : 'Summary'}}
{{lang === 'en_US' ? '中' : 'Eng'}}
Chat more with AI
Powered by AMiner. Clicking this button will take you away from SciOpen.
Home Genes & Diseases Article
PDF (1.2 MB)
Cite
EndNote(RIS) BibTeX
Collect
Submit Manuscript AI Chat Paper
Show Outline
Outline
Show full outline
Hide outline
Outline
Show full outline
Hide outline
Review Article | Open Access

tRNA-derived small RNAs in digestive tract diseases: Progress and perspectives

Mingrui Liua,b,c,1, Xiaojun Zhuangd,1, Haiqing Zhanga,1, Weidong Jia( ), Gang Yuanc,e,f( )
Center for Translational Medicine, The First Affiliated Hospital, Sun Yat-sen University Guangzhou, Guangdong 510080, China
School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, Guangdong 510006, China
Department of Geriatrics, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, Guangdong 510080, China
Department of Gastroenterology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510080, China
International Medical Center, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, Guangdong 510080, China
Phase I Clinical Trial Center, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, Guangdong 510080, China

Peer review under the responsibility of the Genes & Diseases Editorial Office, in alliance with the Association of Chinese Americans in Cancer Research (ACACR, Baltimore, MD, USA).

1 These authors contributed equally to this work.

Show Author Information

Abstract

tRNA-derived small RNAs (tsRNAs) are non-coding small RNAs that are produced through the precise cleavage of tRNA molecules under specific conditions. tsRNA has multiple functions, including inhibiting translation, acting in association with classical small RNA effector mechanisms, or acting in conjunction with Argonaute proteins that affect cell proliferation, migration, cycle, and apoptosis. Recent studies have revealed the clinical potential of tsRNAs in numerous diseases. This article aims to provide a comprehensive and up-to-date review of the classification and biological function of tsRNAs in gastrointestinal diseases. Furthermore, this review explores the underlying mechanisms by which tsRNAs are believed to exert their effects in both tumor and non-tumor digestive tract diseases. Therefore, specific tsRNAs prove promising for disease diagnosis, prognosis prediction, and therapeutic interventions as novel biomarkers for digestive tract diseases.

Keywords

BiogenesisBiological functionDigestive tract diseasesMechanismtRNA-derived small RNAs (tsRNAs)

References

【1】
【1】
 
 
Crossref Google Scholar
Genes & Diseases
Volume 12 Issue 3,
May 2025
Article number: 101326
DOI: 10.1016/j.gendis.2024.101326

{{item.num}}

Comments on this article

Go to comment

< Back to all reports

Review Status: {{reviewData.commendedNum}} Commended , {{reviewData.revisionRequiredNum}} Revision Required , {{reviewData.notCommendedNum}} Not Commended Under Peer Review

Review Comment

Cite this Report
Close
Close
Cite this article:
Liu M, Zhuang X, Zhang H, et al. tRNA-derived small RNAs in digestive tract diseases: Progress and perspectives. Genes & Diseases, 2025, 12(3): 101326. https://doi.org/10.1016/j.gendis.2024.101326

255

Views

1

Downloads

4

Crossref

5

Web of Science

5

Scopus

0

CSCD
Received: 09 November 2023
Revised: 06 March 2024
Accepted: 12 March 2024
Published: 13 May 2024
© 2024 The Authors.

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).