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Rapid Communication | Open Access

SUV39H1-driven NFATc1 methylation is essential for the c-Cbl-mediated degradation of NFATc1 in an osteoclast lineage

Do-Won Jeonga,b,1, Hye-Jin Kima,b,1, Jong-Wan Parka,c, Seulbee Leea,b, Hyeryeon Jungd, Eugene C. Yid, Nacksung Kime, Yang-Sook Chuna,b,c( )
Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul 03080, Republic of Korea
Department of Physiology, Seoul National University College of Medicine, Seoul 03080, Republic of Korea
Ischemic/Hypoxic Disease Institute, Seoul National University College of Medicine, Seoul 03080, Republic of Korea
Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology and College of Medicine Or College of Pharmacy, Seoul National University, Seoul 03080, Republic of Korea
Department of Pharmacology, Chonnam National University Medical School, Gwangju 61469, Republic of Korea

1 These authors contributed equally to this work.

Peer review under responsibility of Chongqing Medical University.

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Genes & Diseases
Volume 11 Issue 4,
July 2024
Article number: 101034
DOI: 10.1016/j.gendis.2023.06.008

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Jeong D-W, Kim H-J, Park J-W, et al. SUV39H1-driven NFATc1 methylation is essential for the c-Cbl-mediated degradation of NFATc1 in an osteoclast lineage. Genes & Diseases, 2024, 11(4): 101034. https://doi.org/10.1016/j.gendis.2023.06.008

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Received: 04 August 2022
Published: 14 July 2023
© 2023 The Authors.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).